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2005年05月13日于科学《科学》（Science）期刊上，美国西北大学的研究团队发布发现生理时钟的基因调控网络与人体代谢有密切连结的研究。研究显示生理时钟失衡会大幅提高糖尿病等代谢症候群的发生风险，显示功能不相关的基因群可能也会存在意想不到的互动和调控机制。这些结果表明，生物钟基因网络在哺乳动物能量平衡中起重要作用。
参考文献
http://www.ncbi.nlm.nih.gov/pubmed/15845877
图片来源
http://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(12)00051-3
