GENE ONLINE|News &
TALEN Proves to be a Better Gene Editor than CRISPR in Densely Packed DNA
Apart from CRISPR, there have been many genome editing technologies that have been tried and tested. TALENs (Transcription activator-like effector nuclease) are widely used to scan, target, and edit DNA. They are similar to Cas9 in their recognition of signature DNA sequence but differ in their target-binding mode.
TALENs can be customized to recognize an array of 33-34 amino acid sequences, which enables DNA-binding to the target. A new report in Nature Communications demonstrated that TALEN could outperform CRISPR in certain regions of DNA.
TALENs can be customized to recognize an array of 33-34 amino acid sequences, which enables DNA-binding to the target. A new report in Nature Communications demonstrated that TALEN could outperform CRISPR in certain regions of DNA.
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